Perineural invasion in oral cancer: challenges, controversies and clinical impact
نویسندگان
چکیده
منابع مشابه
Risks and clinical implications of perineural invasion in T1-2 oral tongue squamous cell carcinoma.
BACKGROUND Risks of perineural invasion (PNI) in T1-2 oral tongue squamous cell carcinoma (SCC) have not been specifically elucidated. METHODS Pathological features, including PNI, were re-reviewed under regular hematoxylin-eosin staining in 190 patients with T1-2 oral tongue SCC. RESULTS Tumor thickness >5 mm, PNI(+), and lymphovascular invasion (+) independently predicted lymph node invol...
متن کاملMandibular Canal Widening and Bell's Palsy: Sequelae of Perineural Invasion in Oral Cancer
Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submuco...
متن کاملClinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer.
OBJECTIVES This study is conducted to show the relationship between visceral pleural, lymphovascular, and perineural invasion, and other clinicopathologic characteristics and their significance as prognostic factors. METHODS The clinicopathologic characteristics of 289 patients who underwent a potentially curative surgical resection between 2000 and 2009 in our clinic were reviewed retrospect...
متن کاملAssociation of diabetes and perineural invasion in pancreatic cancer
Diabetes and perineural invasion are frequently observed in pancreatic cancer. In this study, we tested possible relations between diabetes and perineural invasion in patients with resected pancreatic cancer. We conducted a retrospective study in 544 cases of resected pancreatic adenocarcinoma seen at the University of Texas MD Anderson Cancer Center during 1996-2011. Information on tumor chara...
متن کاملA clinicopathological study of perineural invasion and vascular invasion in oral tongue squamous cell carcinoma.
The risk factors for recurrence of head and neck cancer are classified as being of high or intermediate risk. Those of intermediate risk include multiple positive nodes without extracapsular nodal spread, perineural/vascular invasion, pT3/T4 primary tumours, and positive level IV/V nodes. However, little evidence is available to validate these intermediate risk factors. We analyzed perineural/v...
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ژورنال
عنوان ژورنال: Chinese Clinical Oncology
سال: 2019
ISSN: 2304-3865,2304-3873
DOI: 10.21037/cco.2018.11.04